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KMID : 0869120080100020176
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기초간호자연과학회지
2008 Volume.10 No. 2 p.176 ~ p.183
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The Effects of Environmental Enrichment on Improvement of Motor Function in Parkinson’s Disease Animal Model
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Kang Kyoung-Ah
Han Sang-Sook
Kim Kyung-Hee
Kim Youn-Jung
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Abstract
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Purpose: The purpose of this study was to identify the effect of Environmental Enrichment (EE) on improvement of motor function in animal models of Parkinson’s Disease.
Methods: Male C57BL6 mice weighing 25-30 g, at the age of 12 wks were used in this study. The animals were injected MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridin, 20 mg/kg in saline, i.p.) 4 times a day at every 2 hr, and raised in EE cage for 14 days. On day 14, after behavior test, all mice were sacrificed for immunohistochemistry. All values were expressed as means±S.E.M. Statistical significance was evaluated using a one way ANOVA followed by Sheffe test.
Results: There was a significant difference between the experimental group and the control group in the behavior test. Also EE significantly reduced of TH positive cell loss in Substantia nigra pars compacta as compared to the result of MPTP treatment.
Conclusion: Based on these findings, it is reasonable to assume that the environmental enrichment prevents dopaminergic neuronal loss and improves disarrangement of motor function and behavioral disability induced by MPTP.
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KEYWORD
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Parkinson’s disease, MPTP, Environmental enrichment, Motor function
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